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What is Alendronate Sodium?
- Alendronate sodium is the generic name for Fosamax (brand name). Fosamax is chemically known as a bisphosphonate medication. It is not a hormone. Fosamax works only on the bone and does not affect the heart, breast, uterus or other parts of the body. Alendronate sodium (Fosamax) is taken for the prevention or treatment of osteoporosis in postmenopausal women and men. In addition, Fosamax is approved for the treatment of women and men with osteoporosis resulting from the long-term use of steroid medications such as prednisone or cortisone. Alendronate sodium (Fosamax) is FDA-approved for the prevention or treatment of osteoporosis in postmenopausal women and men. In addition, Fosamax is approved for the treatment of women and men with osteoporosis resulting from the long-term use of steroid medications such as prednisone or cortisone.
- For osteoporosis prevention, Alendronate Sodium is available as a 5mg tablet taken daily or a 35mg tablet taken once a week. For osteoporosis treatment, Fosamax is approved as a 10mg tablet taken daily or a 70mg tablet taken once a week. In addition, for osteoporosis treatment, the FDA recently approved alendronate sodium/cholecalciferol (Fosamax Plus D) a single, once-weekly tablet containing both 70mg alendronate sodium (Fosamax) and 2800IU of vitamin D (representing 7 days worth of 400IU of vitamin D). When taking Fosamax, it is recommended to get adequate calcium and vitamin D each day. It also important to follow the universal strategies for promotion of healthy bones.
- Clinical studies show alendronate sodium increases the bone mineral density of the existing skeleton and reduces the risk of all osteoporosis-related fractures (fractures of the spine and other non-spine areas including the hips) in patients with osteoporosis.
- The side effects of Fosamax may include heartburn and irritation of the esophagus but can usually be avoided by taking the medication properly. Fosamax must be taken first thing in the morning on an empty stomach with a full glass of tap water. Do not take Fosamax with any other beverages such as mineral water, juice, milk, coffee or tea. After taking this medication, you must remain upright (in a sitting or standing position) and avoid bending over or lying down for at least 30 minutes.
- aluminum hydroxide
- antacids
- anti-inflammatory drugs like ibuprofen, naproxen, and others
- aspirin
- calcium supplements
- iron supplements
- magnesium supplements
- parathyroid hormone
- teriparatide
- vitamins with minerals
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Drug Uses
Fosamax is indicated for treatment and prevention of osteoporosis in postmenopausal women. For the treatment of osteoporosis, Fosamax increases bone mass and reduces the incidence of fractures, including those of the hip and spine. It is also indicated for the prevention of osteoporosis, treatment to increase bone mass in men with osteoporosis, treatment of glucocorticoid. It is used to treat induced osteoporosis in men and women receiving glucocorticoids in a daily dosage equivalent to 7.5 mg or greater of prednisone and who have low bone mineral density, treatment of Paget's disease of bone in men and women.
How Taken
Fosamax comes as a tablet to take by mouth. It should be taken once a day in the morning on an empty stomach. Fosamax should be taken with a full glass (6-8 ounces) of plain water. Wait at least 30 minutes after taking Fosamax before you eat, drink, or take other medications. Do not take Fosamax with mineral water, coffee, orange juice, milk, or other dairy products. Do not suck or chew the tablet; swallow the tablet whole. Do not lie down for at least 30 minutes after taking Fosamax. Standing or sitting upright helps you get the full dose and decreases heartburn or the risk of injury to your esophagus.
Warnings/Precautions
Before taking Fosamax, tell your doctor if you have a problem swallowing, such as a narrowing of the esophagus; have esophageal ulcers or an esophageal disease; have a condition that causes low levels of calcium in the body; have kidney disease; have stomach ulcers or other stomach or digestive problems; or are unable to stand or sit upright for at least 30 minutes. You may not be able to take Fosamax, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Fosamax is in the FDA pregnancy category C. This means that it is not known whether Fosamax will be harmful to an unborn baby. Do not take Fosamax without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether Fosamax passes into breast milk. Do not take Fosamax without first talking to your doctor if you are breast-feeding a baby.
Missed Dose
If you take Fosamax every day and you miss a dose, skip that dose and take the next regularly scheduled dose the following day. Missing one dose will not affect your treatment. Do not take two tablets at the same time. If you take a Fosamax once a week and you miss a dose, take the missed dose on the morning after you remember. Do not take two tablets on the same day. Return to taking one tablet once a week, as originally scheduled on your chosen day.
Possible Side Effects
Stop taking Fosamax if you experience any of the following serious side effects: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); Seek emergency or talk to your doctor if you have difficulty or pain when swallowing; chest pain; pain or burning under the ribs or in the back; or new or worsening heartburn. Other, less serious side effects may be more likely to occur. Continue to take Fosamax and talk to your doctor if you experience abdominal discomfort; stomach upset, nausea, vomiting, diarrhea, or constipation; headache; muscle, bone, or joint soreness or aches; eye pain; a rash; or an altered sense of taste. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
Storage
Store in a well-closed container at room temperature, 15-30°C (59-86°F).
Overdose
Hypocalcemia, hypophosphatemia, and upper gastrointestinal adverse events, such as upset stomach, heartburn, esophagitis, gastritis, or ulcer, may result from oral over dosage. If you do think that an overdose has occurred, call an emergency room or poison control center.
More Information
Follow you doctor's recommendations about drinking alcohol and smoking. These activities are related to decreased bone density. Antacids and other medicines taken by mouth may decrease the effects of Fosamax. Do not take any other medicines within 30 minutes after a dose of Fosamax. Talk to your doctor before taking any other medicines during treatment with Fosamax.
Disclaimer
This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.
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